LUMBAR¶
Table Description: Lumbar Puncture
Detailed notes for this table are included below.
View Source CRFs¶
1.0 CRFs: Click on any PAG_NAME link below to be taken to the CRF used in the PPMI 1.0 Study.
2.0 CRFs: Click on any PAG_NAME link below to be taken to a screenshot of how this eCRF is currently implemented in the PPMI 2.0 Study.
2.0 Data Dictionary¶
Table Constraints: PATNO, VISIT_ID
ITM_NAME |
DSCR |
ITM_TYPE |
DSCR_1.0 |
ITM_TYPE_1.0 |
|---|---|---|---|---|
CSFCOLL |
Lumbar puncture for CSF |
NUMBER |
Lumbar puncture for CSF |
CHAR |
LPNDRSN |
Lumbar puncture not done reason |
NUMBER |
Lumbar puncture not done reason |
CHAR |
LPNDRSNCM |
Other lumbar puncture not done reason comment |
TEXT |
||
LMDT |
Date of last intake of food |
DATE |
Date of last intake of food |
DATE |
LMTM |
Time of last intake of food |
TIME |
Time of last intake of food |
TIME |
FASTSTAT |
Fasting Status |
NUMBER |
Fasting Status |
CHAR |
PDMEDYN |
Is subject on medication for PD |
BOOLEAN |
Is subject on medication for PD |
CHAR |
PDMEDDT |
Date of most recent PD med dose |
DATE |
Date of most recent PD med dose |
DATE |
PDMEDTM |
Time of most recent PD med dose |
TIME |
Time of most recent PD med dose |
TIME |
CSFNEEDL |
Needle used for CSF |
NUMBER |
Needle used for CSF |
CHAR |
CSFNEEDLCM |
Other needle used for CSF comment |
TEXT |
||
CSFMETHD |
Method used for CSF |
NUMBER |
Method used for CSF |
CHAR |
LPSITE |
Lumbar puncture site |
NUMBER |
Lumbar puncture site |
CHAR |
LPPOSITN |
Lumbar puncture position |
NUMBER |
Lumbar puncture position |
CHAR |
LPPOSITNCM |
Other lumbar puncture position comment |
TEXT |
||
CSFTM |
Time CSF collected |
TIME |
Time CSF collected |
TIME |
CSFVPRI |
Volume of CSF collected (milliliters) |
NUMBER |
Volume of CSF collected |
NUMBER |
CSFSPNTM |
Time CSF centrifuge |
TIME |
Time CSF centrifuge |
TIME |
CSFSPNRT |
CSF spin rate (xg) |
NUMBER |
CSF spin rate |
NUMBER |
CSFSPNDR |
Duration of CSF centrifugation (minutes) |
NUMBER |
Duration of CSF centrifugation |
NUMBER |
CSFCFRG |
CSF spin temperature (Celsius) |
NUMBER |
CSF spin temperature |
NUMBER |
CSFALQTM |
Time CSF aliquotted |
TIME |
Time CSF aliquotted |
TIME |
CSFVAFT |
Volume of CSF aliquotted (milliliters) |
NUMBER |
Volume of CSF aliquotted |
NUMBER |
CSFALQN |
Number of aliquot tubes |
NUMBER |
Number of aliquot tubes |
NUMBER |
SMPDSCRD |
Bloody tap |
BOOLEAN |
Bloody tap |
CHAR |
CSFST |
CSF storage |
NUMBER |
||
CSFSTTMP |
CSF freezer temp (Celsius) |
NUMBER |
CSF freezer temp |
NUMBER |
CSFFFTM |
Time CSF was either placed in freezer or placed on dry ice |
TIME |
CSF placed in freezer |
TIME |
SMPLOCAL |
Sample sent to local lab |
NUMBER |
Sample sent to local lab |
CHAR |
SMPLOCALCM |
Sample not sent to local lab comment |
TEXT |
||
WBCRSLT |
White blood cell count (per cubic microliter) |
NUMBER |
White blood cell count |
NUMBER |
RBCRSLT |
Red blood cell count (per cubic microliter) |
NUMBER |
Red blood cell count |
NUMBER |
TOPRRSLT |
Total protein (mg/dL) |
NUMBER |
Total protein |
NUMBER |
TGLCRSLT |
Total glucose (mg/dL) |
NUMBER |
Total glucose |
NUMBER |
FLUORO |
Was fluoroscopy performed |
BOOLEAN |
Was fluoroscopy performed |
CHAR |
FLUORODT |
Date of fluoroscopy |
DATE |
Date of fluoroscopy |
DATE |
SPFI |
Was lumbar spine film performed |
BOOLEAN |
Was lumbar spine film performed |
CHAR |
SPFIDT |
Date of spine film |
DATE |
Date of spine film |
DATE |
SPFGUIDE |
Reason for use of additional guidance |
NUMBER |
2.0 Code Book¶
ITM_NAME |
CODE |
DECODE_2.0 |
DECODE_1.0 |
|---|---|---|---|
CSFCOLL |
0 |
Not Done |
Not Done |
CSFCOLL |
1 |
Collected |
Collected |
CSFCOLL |
2 |
Partial Collection |
Partial Collection |
CSFCOLL |
3 |
Attempted, no collection |
Attempted, no collection |
CSFMETHD |
1 |
Gravity |
Gravity |
CSFMETHD |
2 |
Syringe suction |
Syringe suction |
CSFNEEDL |
1 |
20g Quincke (sharp bevelled) needle |
20g Quincke (sharp bevelled) needle |
CSFNEEDL |
2 |
22g Quincke (sharp bevelled) needle |
22g Quincke (sharp bevelled) needle |
CSFNEEDL |
3 |
25g Quincke (sharp bevelled) needle |
25g Quincke (sharp bevelled) needle |
CSFNEEDL |
4 |
22g Sprotte (atraumatic) needle |
22g Sprotte (atraumatic) needle |
CSFNEEDL |
5 |
24g Sprotte (atraumatic) needle |
24g Sprotte (atraumatic) needle |
CSFNEEDL |
6 |
18g |
18g |
CSFNEEDL |
7 |
Other |
Other, Specify in comments |
CSFST |
1 |
Freezer |
|
CSFST |
2 |
Placed on dry ice |
|
FASTSTAT |
1 |
Fasted (minimum of 8 hours) |
Fasted (minimum of 8 hours) |
FASTSTAT |
2 |
Low-Fat Diet |
Low Fat Diet |
FASTSTAT |
3 |
Not Fasted, No Low Fat Diet |
Not Fasted, No Low Fat Diet |
FLUORO |
0 |
No |
No |
FLUORO |
1 |
Yes |
Yes |
LPNDRSN |
1 |
Participant refused |
subj refused/not feeling well |
LPNDRSN |
2 |
Participant not feeling well enough to attempt |
site issues (e.g. scheduling) |
LPNDRSN |
3 |
Site issues (e.g., scheduling difficulties on site end) |
subj hx of difficulty obtaining LP |
LPNDRSN |
4 |
History of difficulty obtaining LP (e.g., participant unable to tolerate procedure in the past; adverse events associated with prior lumbar punctures) |
due to spinal issues |
LPNDRSN |
5 |
Spinal issues (e.g., recent back surgery, spinal stenosis, etc.) |
medical contraindications to LP |
LPNDRSN |
6 |
Medical contraindications to lumbar puncture (e.g., started anticoagulants, lab results, altered mentation, focal neurologic signs, papilledema, seizures, tumor) |
on meds that preclude LP |
LPNDRSN |
7 |
Hyposmic with permission to forego LP |
hyposmic with permission to forego LP |
LPNDRSN |
8 |
other, specify |
|
LPNDRSN |
10 |
Other |
|
LPPOSITN |
1 |
Sitting, leaned over (preferred) |
Sitting, leaned over |
LPPOSITN |
2 |
Lying, curled up on side |
Lying, curled up on side |
LPPOSITN |
3 |
Prone |
Unknown |
LPPOSITN |
4 |
Unknown |
Other, specify in comments |
LPPOSITN |
5 |
Other |
|
LPSITE |
0 |
L2-L3 Interspace |
|
LPSITE |
1 |
L2-L3 Interspace |
L3-L4 Interspace |
LPSITE |
2 |
L3-L4 Interspace |
L4-L5 Interspace |
LPSITE |
3 |
L4-L5 Interspace |
Unknown |
LPSITE |
4 |
L5-S1 Interspace |
|
LPSITE |
5 |
Unknown |
|
PDMEDYN |
0 |
No |
No |
PDMEDYN |
1 |
Yes |
Yes |
SMPDSCRD |
0 |
No |
No |
SMPDSCRD |
1 |
Yes |
Yes |
SMPLOCAL |
0 |
No |
No |
SMPLOCAL |
1 |
Yes |
Yes |
SMPLOCAL |
2 |
Site exemption |
|
SPFGUIDE |
1 |
Previously failed attempt |
|
SPFGUIDE |
2 |
Uncertain about location |
|
SPFGUIDE |
3 |
Part of standard procedure |
|
SPFGUIDE |
4 |
Other |
|
SPFI |
0 |
No |
No |
SPFI |
1 |
Yes |
Yes |
Missing Columns¶
ITM_NAME |
DSCR_1.0 |
|---|---|
COMM |
Comments |
CSFDT |
Date CSF collected |
RBCOTHCM |
RBC Units - other |
RBCUNITB |
Red blood cell count units-mm3 mcL L oth |
TGLCUNIT |
Total glucose units |
TOPRUNIT |
Total protein units |
WBCOTHCM |
WBC Units - other |
WBCUNITB |
Wht blood cell count units-mm3 mcL L oth |
Details¶
The LUMBAR table captures data around the Lumbar Puncture procedure. The form is collected regularly throughout the study each time CSF is collected from participants.
LPNDRSN
The possible values for this variable have been harmonized to account for versions of the form that were used both in the original and extended phases of the PPMI study. “Other” in the extended version was recoded from 7 to 10 and a new 7 code was added to account for a possible value in the original version of the form.