FAMHXPD¶

Table Description: Family History

Detailed notes for this table are included below.

1.0 Description: Family History (PD)

View Source CRFs¶

1.0 CRFs: Click on any PAG_NAME link below to be taken to the CRF used in the PPMI 1.0 Study.

FAMHXPD

2.0 CRFs: Click on any PAG_NAME link below to be taken to a screenshot of how this eCRF is currently implemented in the PPMI 2.0 Study.

FAMHXPD

2.0 Data Dictionary¶

Table Constraints: PATNO, VISIT_ID

ITM_NAME	DSCR	ITM_TYPE	DSCR_1.0	ITM_TYPE_1.0
FULBRO	Full Brothers	NUMBER
FULSIS	Full Sisters	NUMBER
MAHAFSIB	Maternal Half Siblings	NUMBER
PAHAFSIB	Paternal Half Siblings	NUMBER
MATAU	Maternal Aunts and Uncles	NUMBER	Maternal Aunts and Uncles	NUMBER
PATAU	Paternal Aunts and Uncles	NUMBER	Paternal Aunts and Uncles	NUMBER
MATCOUS	Maternal Cousins	NUMBER
PATCOUS	Paternal Cousins	NUMBER
KIDSNUM	Children	NUMBER	How many children do you have	NUMBER
ANYFAMPD	Do you have any family history of Parkinson’s Disease or Parkinsonism?	BOOLEAN
BIOMOMPD	Biological Mother with PD or Parkinsonism	BOOLEAN	Biological Mother with PD	NUMBER
BIODADPD	Biological Father with PD or Parkinsonism	BOOLEAN	Biological Father with PD	NUMBER
MAGMOTHPD	Maternal Grandmother with PD or Parkinsonism	BOOLEAN
MAGFATHPD	Maternal Grandfather with PD or Parkinsonism	BOOLEAN
PAGMOTHPD	Paternal Grandmother with PD or Parkinsonism	BOOLEAN
PAGFATHPD	Paternal Grandfather with PD or Parkinsonism	BOOLEAN
FULBROPD	Full Brothers with PD or Parkinsonism	NUMBER
FULSISPD	Full Sisters with PD or Parkinsonism	NUMBER
MAHAFSIBPD	Maternal Half Siblings with PD or Parkinsonism	NUMBER
PAHAFSIBPD	Paternal Half Siblings with PD or Parkinsonism	NUMBER
MATAUPD	Maternal Aunts and Uncles with PD or Parkinsonism	NUMBER	Maternal Aunts and Uncles with PD	NUMBER
PATAUPD	Paternal Aunts and Uncles with PD or Parkinsonism	NUMBER	Paternal Aunts and Uncles with PD	NUMBER
MATCOUSPD	Maternal Cousins with PD or Parkinsonism	NUMBER
PATCOUSPD	Paternal Cousins with PD or Parkinsonism	NUMBER
KIDSPD	Children with PD or Parkinsonism	NUMBER	How many children with PD	NUMBER
DISFAMPD	Do you have a more distant relative not listed above who has/had Parkinson’s disease or Parkinsonism?	BOOLEAN

2.0 Code Book¶

ITM_NAME	CODE	DECODE_2.0
ANYFAMPD	0	No
ANYFAMPD	1	Yes
BIODADPD	0	No
BIODADPD	1	Yes
BIOMOMPD	0	No
BIOMOMPD	1	Yes
DISFAMPD	0	No
DISFAMPD	1	Yes
MAGFATHPD	0	No
MAGFATHPD	1	Yes
MAGMOTHPD	0	No
MAGMOTHPD	1	Yes
PAGFATHPD	0	No
PAGFATHPD	1	Yes
PAGMOTHPD	0	No
PAGMOTHPD	1	Yes

Missing Columns¶

ITM_NAME	DSCR_1.0
BIODAD	Biological Father
BIOMOM	Biological Mother
FULSIB	Full Siblings
FULSIBPD	Full Siblings with PD
HAFSIB	Half Siblings
HAFSIBPD	Half Siblings with PD
MAGPAR	Maternal Grandparents
MAGPARPD	Maternal Grandparents with PD
PAGPAR	Paternal Grandparents
PAGPARPD	Paternal Grandparents with PD
STAFFCD	Examiner

Details¶

This CRF was redesigned in PPMI 2.0 to simplify it and to take advantage of conditional logic to avoid errors.

ANYFAMPD

If the answer to this variable is No, then none of the PD questions for individual family members will be collected. This means that, unlike in 1.0, there may be null values instead of zeros in these columns.

BIOMOMPD, BIODADPD, MAGMOTHPD, MAGFATHPD, PAGMOTHPD, PAGFATHPD

These variables are represented as booleans in 2.0, but were continuous variables in 1.0. Additionally, any total number of family member question associated with these categories have been removed. The assumption is that the total number is always 1 for all these family members.

Family Member Sub-Divisions

The way in which different categories of family members are divided has changed between PPMI 1.0 and 2.0. A summary of how each category is captured is below:

		Total	PD
Mother	1.0	BIOMOM	BIOMOMPD
	2.0		BIOMOMPD
Father	1.0	BIODAD	BIODADPD
	2.0		BIODADPD
Siblings	1.0	FULSIB	FULSIBPD
	2.0	FULBRO	FULBROPD
		FULSIS	FULSISPD
Half Siblings	1.0	HAFSIB	HAFSIBPD
	2.0	MAHAFSIB	MAHAFSIBPD
		PAHAFSIB	PAHAFSIBPD
Maternal Grandparents	1.0	MAGPAR	MAGPARPD
	2.0		MAGMOTHPD
			MAGFATHPD
Paternal Grandparents	1.0	PAGPAR	PAGPARPD
	2.0		PAGMOTHPD
			PAGFATHPD
Maternal Aunts and Uncles	1.0	MATAU	MATAUPD
	2.0	MATAU	MATAUPD
Paternal Aunts and Uncles	1.0	PATAU	PATAUPD
	2.0	PATAU	PATAUPD
Maternal Cousins	1.0
	2.0	MATCOUS	MATCOUSPD
Paternal Cousins	1.0
	2.0	PATCOUS	PATCOUSPD
Children	1.0	KIDSNUM	KIDSPD
	2.0	KIDSNUM	KIDSPD

Future State

For the purpose of analytic utility, most of the missing variables have been marked as DERIVED. Though we are no longer directly capturing this information in PPMI 2.0, it can be easily derived from the data that we do have, or can be imputed with the assumption that all participants have one of each Mother, Father, and Maternal and Fraternal Grandmothers and Grandfathers.