NUPDRS1

Table Description: MDS-UPDRS Part I: Non-Motor Aspects of Experiences of Daily Living (nM-EDL)

Detailed notes for this table are included below.

1.0 Description: nUPDRS Part I

View Source CRFs

2.0 CRFs: Click on any PAG_NAME link below to be taken to a screenshot of how this eCRF is currently implemented in the PPMI 2.0 Study.

2.0 Data Dictionary

Table Constraints: PATNO, VISIT_ID

ITM_NAME

DSCR

ITM_TYPE

ITM_TYPE_1.0

NUPSOURC

Primary Source of Information

NUMBER

CHAR

NP1COG

COGNITIVE IMPAIRMENT

TEXT

NUMBER

NP1HALL

HALLUCINATIONS AND PSYCHOSIS

TEXT

NUMBER

NP1DPRS

DEPRESSED MOODS

TEXT

NUMBER

NP1ANXS

ANXIOUS MOOD

TEXT

NUMBER

NP1APAT

APATHY

TEXT

NUMBER

NP1DDS

FEATURES-DOPAMINE DYSREGULATION SYNDROME

TEXT

NUMBER

2.0 Code Book

ITM_NAME

CODE

DECODE_2.0

DECODE_1.0

NP1ANXS

0

Normal: No anxious feelings.

NP1ANXS

1

Slight: Anxious feelings present but not sustained for more than one day at a time. No interference with patient’s ability to carry out normal activities and social interactions.

NP1ANXS

2

Mild: Anxious feelings are sustained over more than one day at a time, but without interference with patient’s ability to carry out normal activities and social interactions.

NP1ANXS

3

Moderate: Anxious feelings interfere with, but do not preclude, the patient’s ability to carry out normal activities and social interactions.

NP1ANXS

4

Severe: Anxious feelings preclude patient’s ability to carry out normal activities and social interactions.

NP1ANXS

UR

Unable to Rate

NP1APAT

0

Normal: No apathy.

NP1APAT

1

Slight: Apathy appreciated by patient and/or caregiver, but no interference with daily activities and social interactions.

NP1APAT

2

Mild: Apathy interferes with isolated activities and social interactions.

NP1APAT

3

Moderate: Apathy interferes with most activities and social interactions.

NP1APAT

4

Severe: Passive and withdrawn, complete loss of initiative.

NP1APAT

UR

Unable to Rate

NP1COG

0

Normal: No cognitive impairment.

NP1COG

1

Slight: Impairment appreciated by patient or caregiver with no concrete interference with the patient’s ability to carry out normal activities and social interactions.

NP1COG

2

Mild: Clinically evident cognitive dysfunction, but only minimal interference with the patient’s ability to carry out normal activities and social interactions.

NP1COG

3

Moderate: Cognitive deficits interfere with but do not preclude the patient’s ability to carry out normal activities and social interactions.

NP1COG

4

Severe: Cognitive dysfunction precludes the patient’s ability to carry out normal activities and social interactions.

NP1COG

UR

Unable to Rate

NP1DDS

0

Normal: No problems present. .

NP1DDS

1

Slight: Problems are present but usually do not cause any difficulties for the patient or family/caregiver.

NP1DDS

2

Mild: Problems are present and usually cause a few difficulties in the patient’s personal and family life.

NP1DDS

3

Moderate: Problems are present and usually cause a lot of difficulties in the patient’s personal and family life.

NP1DDS

4

Severe: Problems are present and preclude the patient’s ability to carry out normal activities or social interactions or to maintain previous standards in personal and family life.

NP1DDS

UR

Unable to Rate

NP1DPRS

0

Normal: No depressed mood.

NP1DPRS

1

Slight: Episodes of depressed mood that are not sustained for more than one day at a time. No interference with patient’s ability to carry out normal activities and social interactions.

NP1DPRS

2

Mild: Depressed mood that is sustained over days, but without interference with normal activities and social interactions.

NP1DPRS

3

Moderate: Depressed mood that interferes with, but does not preclude the patient’s ability to carry out normal activities and social interactions.

NP1DPRS

4

Severe: Depressed mood precludes patient’s ability to carry out normal activities and social interactions.

NP1DPRS

UR

Unable to Rate

NP1HALL

0

Normal: No hallucinations or psychotic behavior.

NP1HALL

1

Slight: Illusions or non-formed hallucinations, but patient recognizes them without loss of insight.

NP1HALL

2

Mild: Formed hallucinations independent of environmental stimuli. No loss of insight.

NP1HALL

3

Moderate: Formed hallucinations with loss of insight.

NP1HALL

4

Severe: Patient has delusions or paranoia.

NP1HALL

UR

Unable to Rate

NUPSOURC

1

Patient

Patient

NUPSOURC

2

Caregiver

Caregiver

NUPSOURC

3

Patient and Caregiver in Equal Proportion

Patient and Caregiver - Equal Proportion

Missing Columns

ITM_NAME

DSCR_1.0

STAFFCD

Examiner

Details

The NUPDRS1 CRF has remained conceptually consistent between PPMI 1.0 and 2.0. Two design differences have been noted below.

ITM_TYPE

ITM_TYPE has changed for nearly every variable because in PPMI 2.0 the “Unable to Rate” option is captured in the list of possible values as “UR”, while in PPMI 1.0 only the numeric option 0-4 were listed.

Codebook

Besides NUPRSOURC, no variables from the NUPDRS1 table were included in PPMI 1.0’s Code List. In 2.0, all variables from the NUPDRS1 table have been added to the codebook to allow for documentation on what the different codes mean for each question. The DIFF REASON of “DESIGN” indicates that these were added to the code book as a result of the design of the CRF in the EDC, which includes both numeric and text options.