NUPDRS4¶
Table Description: MDS-UPDRS Part IV: Motor Complications
Detailed notes for this table are included below.
1.0 Description: nUPDRS Part IV
View Source CRFs¶
2.0 CRFs: Click on any PAG_NAME link below to be taken to a screenshot of how this eCRF is currently implemented in the PPMI 2.0 Study.
2.0 Data Dictionary¶
Table Constraints: PATNO, VISIT_ID
ITM_NAME |
DSCR |
ITM_TYPE |
ITM_TYPE_1.0 |
|---|---|---|---|
NP4WDYSKNUM |
4.1 Total Hours Awake |
NUMBER |
|
NP4WDYSKDEN |
4.1 Total Hours with Dyskinesia |
NUMBER |
|
NP4WDYSKPCT |
4.1 % Dyskinesia |
NUMBER |
|
NP4WDYSK |
4.1 Time spent with dyskinesias |
TEXT |
NUMBER |
NP4DYSKI |
4.2 Functional impact of dyskinesias |
TEXT |
NUMBER |
NP4OFFNUM |
4.3 Total Hours Awake |
NUMBER |
|
NP4OFFDEN |
4.3 Total Hours OFF |
NUMBER |
|
NP4OFFPCT |
4.3 % OFF |
NUMBER |
|
NP4OFF |
4.3 Time spent in the OFF state |
TEXT |
NUMBER |
NP4FLCTI |
4.4 Functional impact of fluctuations |
TEXT |
NUMBER |
NP4FLCTX |
4.5 Complexity of motor fluctuations |
TEXT |
NUMBER |
NP4DYSTNNUM |
4.6 Total Hours OFF |
NUMBER |
|
NP4DYSTNDEN |
4.6 Total Hours OFF with Dystonia |
NUMBER |
|
NP4DYSTNPCT |
4.6 % OFF Dystonia |
NUMBER |
|
NP4DYSTN |
4.6 Painful OFF-state dystonia |
TEXT |
NUMBER |
2.0 Code Book¶
ITM_NAME |
CODE |
DECODE_2.0 |
DECODE_1.0 |
|---|---|---|---|
NP4DYSKI |
0 |
Normal: No dyskinesias or no impact by dyskinesias on activities or social interactions. |
|
NP4DYSKI |
1 |
Slight: Dyskinesias impact on a few activities, but the patient usually performs all activities and participates in all social interactions during dyskinetic periods. |
|
NP4DYSKI |
2 |
Mild: Dyskinesias impact on many activities, but the patient usually performs all activities and participates in all social interactions during dyskinetic periods. |
|
NP4DYSKI |
3 |
Moderate: Dyskinesias impact on activities to the point that the patient usually does not perform some activities or does not usually participate in some social activities during dyskinetic episodes. |
|
NP4DYSKI |
4 |
Severe: Dyskinesias impact on function to the point that the patient usually does not perform most activities or participate in most social interactions during dyskinetic episodes. |
|
NP4DYSKI |
UR |
Unable to Rate |
|
NP4DYSTN |
0 |
Normal: No dystonia OR NO OFF TIME. |
|
NP4DYSTN |
1 |
Slight: <= 25% of time in OFF state. |
|
NP4DYSTN |
2 |
Mild: 26-50% of time in OFF state. |
|
NP4DYSTN |
3 |
Moderate: 51-75% of time in OFF state. |
|
NP4DYSTN |
4 |
Severe: > 75% of time in OFF state. |
|
NP4DYSTN |
UR |
Unable to Rate |
|
NP4FLCTI |
0 |
Normal: No fluctuations or no impact by fluctuations on performance of activities or social interactions. |
|
NP4FLCTI |
1 |
Slight: Fluctuations impact on a few activities, but during OFF, the patient usually performs all activities and participates in all social interactions that typically occur during the ON state. |
|
NP4FLCTI |
2 |
Mild: Fluctuations impact many activities, but during OFF, the patient still usually performs all activities and participates in all social interactions that typically occur during the ON state. |
|
NP4FLCTI |
3 |
Moderate: Fluctuations impact on the performance of activities during OFF to the point that the patient usually does not perform some activities or participate in some social interactions that are performed during ON periods. |
|
NP4FLCTI |
4 |
Severe: Fluctuations impact on function to the point that, during OFF, the patient usually does not perform most activities or participate in most social interactions that are performed during ON periods. |
|
NP4FLCTI |
UR |
Unable to Rate |
|
NP4FLCTX |
0 |
Normal: No motor fluctuations. |
|
NP4FLCTX |
1 |
Slight: OFF times are predictable all or almost all of the time (> 75%). |
|
NP4FLCTX |
2 |
Mild: OFF times are predictable most of the time (51-75%). |
|
NP4FLCTX |
3 |
Moderate: OFF times are predictable some of the time (26-50%). |
|
NP4FLCTX |
4 |
Severe: OFF episodes are rarely predictable (<= 25%). |
|
NP4FLCTX |
UR |
Unable to Rate |
|
NP4OFF |
0 |
Normal: No OFF time. |
|
NP4OFF |
1 |
Slight: <= 25% of waking day. |
|
NP4OFF |
2 |
Mild: 26 - 50% of waking day. |
|
NP4OFF |
3 |
Moderate: 51 - 75% of waking day. |
|
NP4OFF |
4 |
Severe: > 75% of waking day. |
|
NP4OFF |
UR |
Unable to Rate |
|
NP4WDYSK |
0 |
Normal: No dyskinesias. |
|
NP4WDYSK |
1 |
Slight: <= 25% of waking day. |
|
NP4WDYSK |
2 |
Mild: 26 - 50% of waking day. |
|
NP4WDYSK |
3 |
Moderate: 51 - 75% of waking day. |
|
NP4WDYSK |
4 |
Severe: > 75% of waking day. |
|
NP4WDYSK |
UR |
Unable to Rate |
Missing Columns¶
ITM_NAME |
DSCR_1.0 |
|---|---|
STAFFCD |
Examiner |
Details¶
The NUPDRS4 CRF has remained largely consistent between PPMI 1.0 and 2.0. A few differences have been noted below.
Calculation Inputs
Three variables in the NUPDRS4 section require some sort of calculation (total time spent or percent time with a symptom). These variables include NP4DYSTN, NP4OFF, and NP4WDYSK. In the MDS-UPDRS exam, for each of these questions there are three subquestions to help the investigator calculate the correct time/percentage, which then gets translated to a 0-4 scale (i.e., normal, slight, mild, etc.). In PPMI 1.0, only the resulting 0-4 score was recorded for each of these variables. In PPMI 2.0, all three subquestions have been added to the data dictionary.
ITM_TYPE
ITM_TYPE has changed for nearly every variable because in PPMI 2.0 the “Unable to Rate” option is captured in the list of possible values as “UR”, while in PPMI 1.0 only the numeric option 0-4 were listed.
Codebook
Besides NUPRSOURC, no variables from the NUPDRS1 table were included in PPMI 1.0’s Code List. In 2.0, all variables from the NUPDRS1 table have been added to the codebook to document what the different codes mean for each question. The DIFF REASON of “DESIGN” indicates that these were added to the code book as a result of the design of the CRF in the EDC, which includes both numeric and text options.