NUPDRS3¶
Table Description: MDS UPDRS Part III
Detailed notes for this table are included below.
1.0 Description: nUPDRS Part III
View Source CRFs¶
2.0 CRFs: Click on any PAG_NAME link below to be taken to a screenshot of how this eCRF is currently implemented in the PPMI 2.0 Study.
2.0 Data Dictionary¶
Table Constraints: PATNO, VISIT_ID, PAG_NAME
ITM_NAME |
DSCR |
ITM_TYPE |
DSCR_1.0 |
ITM_TYPE_1.0 |
|---|---|---|---|---|
PDTRTMNT |
Is the participant on medication or receiving deep brain stimulation for treating the symptoms of Parkinsons disease? |
BOOLEAN |
||
PDSTATE |
Which functional state is the participant currently in? |
TEXT |
Subject’s PD state during examination |
CHAR |
NP3SPCH |
3.1 Speech |
TEXT |
3.1 Speech |
NUMBER |
NP3FACXP |
3.2 Facial expression |
TEXT |
3.2 Facial expression |
NUMBER |
NP3RIGN |
3.3a Rigidity - Neck |
TEXT |
3.3a Rigidity - Neck |
NUMBER |
NP3RIGRU |
3.3b Rigidity - RUE |
TEXT |
3.3b Rigidity - RUE |
NUMBER |
NP3RIGLU |
3.3c Rigidity - LUE |
TEXT |
3.3c Rigidity - LUE |
NUMBER |
NP3RIGRL |
3.3d Rigidity - RLE |
TEXT |
||
NP3RIGLL |
3.3e Rigidity - LLE |
TEXT |
3.3e Rigidity - LLE |
NUMBER |
NP3FTAPR |
3.4a Finger Tapping Right Hand |
TEXT |
3.4a Finger Tapping Right Hand |
NUMBER |
NP3FTAPL |
3.4b Finger Tapping Left Hand |
TEXT |
3.4b Finger Tapping Left Hand |
NUMBER |
NP3HMOVR |
3.5a Hand movements - Right Hand |
TEXT |
3.5a Hand movements - Right Hand |
NUMBER |
NP3HMOVL |
3.5b Hand movements - Left Hand |
TEXT |
3.5b Hand movements - Left Hand |
NUMBER |
NP3PRSPR |
3.6a Pronation-Supination - Right Hand |
TEXT |
3.6a Pronation-Supination - Right Hand |
NUMBER |
NP3PRSPL |
3.6b Pronation-Supination - Left Hand |
TEXT |
3.6b Pronation-Supination - Left Hand |
NUMBER |
NP3TTAPR |
3.7a Toe tapping - Right foot |
TEXT |
3.7a Toe tapping - Right foot |
NUMBER |
NP3TTAPL |
3.7b Toe tapping - Left foot |
TEXT |
3.7b Toe tapping - Left foot |
NUMBER |
NP3LGAGR |
3.8a Leg agility - Right leg |
TEXT |
3.8a Leg agility - Right leg |
NUMBER |
NP3LGAGL |
3.8b Leg agility - Left leg |
TEXT |
3.8b Leg agility - Left leg |
NUMBER |
NP3RISNG |
3.9 Arising from chair |
TEXT |
3.9 Arising from chair |
NUMBER |
NP3GAIT |
3.10 Gait |
TEXT |
3.10 Gait |
NUMBER |
NP3FRZGT |
3.11 Freezing of gait |
TEXT |
3.11 Freezing of gait |
NUMBER |
NP3PSTBL |
3.12 Postural stability |
TEXT |
3.12 Postural stability |
NUMBER |
NP3POSTR |
3.13 Posture |
TEXT |
3.13 Posture |
NUMBER |
NP3BRADY |
3.14 Global spontaneity of movement |
TEXT |
3.14 Global spontaneity of movement |
NUMBER |
NP3PTRMR |
3.15a Postural tremor - Right Hand |
TEXT |
3.15a Postural tremor - Right Hand |
NUMBER |
NP3PTRML |
3.15b Postural tremor - Left hand |
TEXT |
3.15b Postural tremor - Left hand |
NUMBER |
NP3KTRMR |
3.16a Kinetic tremor - Right hand |
TEXT |
3.16a Kinetic tremor - Right hand |
NUMBER |
NP3KTRML |
3.16b Kinetic tremor - Left hand |
TEXT |
3.16b Kinetic tremor - Left hand |
NUMBER |
NP3RTARU |
3.17a Rest tremor amplitude - RUE |
TEXT |
3.17a Rest tremor amplitude - RUE |
NUMBER |
NP3RTALU |
3.17b Rest tremor amplitude - LUE |
TEXT |
3.17b Rest tremor amplitude - LUE |
NUMBER |
NP3RTARL |
3.17c Rest tremor amplitude - RLE |
TEXT |
3.17c Rest tremor amplitude - RLE |
NUMBER |
NP3RTALL |
3.17d Rest tremor amplitude - LLE |
TEXT |
3.17d Rest tremor amplitude - LLE |
NUMBER |
NP3RTALJ |
3.17e Rest tremor amplitude - Lip/jaw |
TEXT |
3.17e Rest tremor amplitude - Lip/jaw |
NUMBER |
NP3RTCON |
3.18 Constancy of rest tremor |
TEXT |
3.18 Constancy of rest |
NUMBER |
DYSKPRES |
3.19 Were dyskinesias present |
BOOLEAN |
3.19 Were dyskinesias present |
CHAR |
DYSKIRAT |
3.20 Did movements interfere with rating |
BOOLEAN |
3.20 Did movements interfere with rating |
CHAR |
NHY |
3.21 Hoehn and Yahr Stage |
TEXT |
3.21 Hoehn and Yahr Stage |
NUMBER |
PDMEDDT |
Date of most recent PD med dose |
DATE |
Date of most recent PD med dose |
DATE |
PDMEDTM |
Time of most recent PD med dose |
TIME |
Time of most recent PD med dose |
TIME |
DBSOFFTM |
Time DBS turned off before OFF exam |
TIME |
||
DBSONTM |
Time DBS turned on before ON exam |
TIME |
||
EXAMTM |
Time NUPDRS3 exam was administered |
TIME |
Time Part III was administered |
TIME |
HRPOSTMED |
Hours between last dose of PD medication and NUPDRS3 exam |
NUMBER |
||
HRDBSOFF |
Hours between DBS device turned off and NUPDRS3 exam |
NUMBER |
||
HRDBSON |
Hours between DBS device turned on and NUPDRS3 exam |
NUMBER |
2.0 Code Book¶
ITM_NAME |
CODE |
DECODE_2.0 |
DECODE_1.0 |
|---|---|---|---|
DYSKIRAT |
0 |
No |
No |
DYSKIRAT |
1 |
Yes |
Yes |
DYSKPRES |
0 |
No |
No |
DYSKPRES |
1 |
Yes |
Yes |
NHY |
0 |
Asymptomatic. |
|
NHY |
1 |
Unilateral movement only. |
|
NHY |
2 |
Bilateral involvement without impairment of balance. |
|
NHY |
3 |
Mild to moderate involvement; some postural instability but physically independent; needs assistance to recover from pull test. |
|
NHY |
4 |
Severe disability; still able to walk or stand unassisted. |
|
NHY |
5 |
Wheelchair bound or bedridden unless aided. |
|
NHY |
UR |
Unable to Rate |
|
NP3BRADY |
0 |
Normal: No problems. |
|
NP3BRADY |
1 |
Slight: Slight global slowness and poverty of spontaneous movements. |
|
NP3BRADY |
2 |
Mild: Mild global slowness and poverty of spontaneous movements. |
|
NP3BRADY |
3 |
Moderate: Moderate global slowness and poverty of spontaneous movements. |
|
NP3BRADY |
4 |
Severe: Severe global slowness and poverty of spontaneous movements. |
|
NP3BRADY |
UR |
Unable to Rate |
|
NP3FACXP |
0 |
Normal: Normal facial expression. |
|
NP3FACXP |
1 |
Slight: Minimal masked facies manifested only by decreased frequency of blinking. |
|
NP3FACXP |
2 |
Mild: In addition to decreased eye-blink frequency, Masked facies present in the lower face as well, namely fewer movements around the mouth, such as less spontaneous smiling, but lips not parted. |
|
NP3FACXP |
3 |
Moderate: Masked facies with lips parted some of the time when the mouth is at rest. |
|
NP3FACXP |
4 |
Severe: Masked facies with lips parted most of the time when the mouth is at rest. |
|
NP3FACXP |
UR |
Unable to Rate |
|
NP3FRZGT |
0 |
Normal: No freezing. |
|
NP3FRZGT |
1 |
Slight: Freezes on starting, turning or walking through doorway with a single halt during any of these events, but then continues smoothly without freezing during straight walking. |
|
NP3FRZGT |
2 |
Mild: Freezes on starting, turning or walking through doorway with more than one halt during any of these activities, but continues smoothly without freezing during straight walking. |
|
NP3FRZGT |
3 |
Moderate: Freezes once during straight walking. |
|
NP3FRZGT |
4 |
Severe: Freezes multiple times during straight walking. |
|
NP3FRZGT |
UR |
Unable to Rate |
|
NP3FTAPL |
0 |
Normal: No problems. |
|
NP3FTAPL |
1 |
Slight: Any of the following: a) the regular rhythm is broken with one or two interruptions or hesitations of the tapping movement; b) slight slowing; c) the amplitude decrements near the end of the 10 taps. |
|
NP3FTAPL |
2 |
Mild: Any of the following: a) 3 to 5 interruptions during tapping; b) mild slowing; c) the amplitude decrements midway in the 10-tap sequence. |
|
NP3FTAPL |
3 |
Moderate: Any of the following: a) more than 5 interruptions during tapping or at least one longer arrest (freeze) in ongoing movement; b) moderate slowing; c) the amplitude decrements starting after the first tap. |
|
NP3FTAPL |
4 |
Severe: Cannot or can only barely perform the task because of slowing, interruptions or decrements. |
|
NP3FTAPL |
UR |
Unable to Rate |
|
NP3FTAPR |
0 |
Normal: No problems. |
|
NP3FTAPR |
1 |
Slight: Any of the following: a) the regular rhythm is broken with one or two interruptions or hesitations of the tapping movement; b) slight slowing; c) the amplitude decrements near the end of the 10 taps. |
|
NP3FTAPR |
2 |
Mild: Any of the following: a) 3 to 5 interruptions during tapping; b) mild slowing; c) the amplitude decrements midway in the 10-tap sequence. |
|
NP3FTAPR |
3 |
Moderate: Any of the following: a) more than 5 interruptions during tapping or at least one longer arrest (freeze) in ongoing movement; b) moderate slowing; c) the amplitude decrements starting after the first tap. |
|
NP3FTAPR |
4 |
Severe: Cannot or can only barely perform the task because of slowing, interruptions or decrements. |
|
NP3FTAPR |
UR |
Unable to Rate |
|
NP3GAIT |
0 |
Normal: No problems. |
|
NP3GAIT |
1 |
Slight: Independent walking with minor gait impairment. |
|
NP3GAIT |
2 |
Mild: Independent walking but with substantial gait impairment. |
|
NP3GAIT |
3 |
Moderate: Requires an assistance device for safe walking (walking stick, walker) but not a person. |
|
NP3GAIT |
4 |
Severe: Cannot walk at all or only with another person’s assistance. |
|
NP3GAIT |
UR |
Unable to Rate |
|
NP3HMOVL |
0 |
Normal: No problems. |
|
NP3HMOVL |
1 |
Slight: Any of the following: a) the regular rhythm is broken with one or two interruptions or hesitations of the movement; b) slight slowing; c) the amplitude decrements near the end of the task. |
|
NP3HMOVL |
2 |
Mild: Any of the following: a) 3 to 5 interruptions during the movements; b) mild slowing; c) the amplitude decrements midway in the task. |
|
NP3HMOVL |
3 |
Moderate: Any of the following: a) more than 5 interruptions during the movement or at least one longer arrest (freeze) in ongoing movement; b) moderate slowing; c) the amplitude decrements starting after the first open-and-close sequence. |
|
NP3HMOVL |
4 |
Severe: Cannot or can only barely perform the task because of slowing, interruptions or decrements. |
|
NP3HMOVL |
UR |
Unable to Rate |
|
NP3HMOVR |
0 |
Normal: No problems. |
|
NP3HMOVR |
1 |
Slight: Any of the following: a) the regular rhythm is broken with one or two interruptions or hesitations of the movement; b) slight slowing; c) the amplitude decrements near the end of the task. |
|
NP3HMOVR |
2 |
Mild: Any of the following: a) 3 to 5 interruptions during the movements; b) mild slowing; c) the amplitude decrements midway in the task. |
|
NP3HMOVR |
3 |
Moderate: Any of the following: a) more than 5 interruptions during the movement or at least one longer arrest (freeze) in ongoing movement; b) moderate slowing; c) the amplitude decrements starting after the first open-and-close sequence. |
|
NP3HMOVR |
4 |
Severe: Cannot or can only barely perform the task because of slowing, interruptions or decrements. |
|
NP3HMOVR |
UR |
Unable to Rate |
|
NP3KTRML |
0 |
Normal: No tremor. |
|
NP3KTRML |
1 |
Slight: Tremor is present but less than 1 cm in amplitude. |
|
NP3KTRML |
2 |
Mild: Tremor is at least 1, but less than 3 cm in amplitude. |
|
NP3KTRML |
3 |
Moderate: Tremor is at least 3, but less than 10 cm in amplitude. |
|
NP3KTRML |
4 |
Severe: Tremor is at least 10 cm in amplitude. |
|
NP3KTRML |
UR |
Unable to Rate |
|
NP3KTRMR |
0 |
Normal: No tremor. |
|
NP3KTRMR |
1 |
Slight: Tremor is present but less than 1 cm in amplitude. |
|
NP3KTRMR |
2 |
Mild: Tremor is at least 1, but less than 3 cm in amplitude. |
|
NP3KTRMR |
3 |
Moderate: Tremor is at least 3, but less than 10 cm in amplitude. |
|
NP3KTRMR |
4 |
Severe: Tremor is at least 10 cm in amplitude. |
|
NP3KTRMR |
UR |
Unable to Rate |
|
NP3LGAGL |
0 |
Normal: No problems. |
|
NP3LGAGL |
1 |
Slight: Any of the following: a) the regular rhythm is broken with one or two interruptions or hesitations of the movement; b) slight slowing; c) amplitude decrements near the end of the task. |
|
NP3LGAGL |
2 |
Mild: Any of the following: a) 3 to 5 interruptions during the movements; b) mild slowness; c) amplitude decrements midway in the task. |
|
NP3LGAGL |
3 |
Moderate: Any of the following: a) more than 5 interruptions during the movements or at least one longer arrest (freeze) in ongoing movement; b) moderate slowing in speed; c) amplitude decrements after the first movement. |
|
NP3LGAGL |
4 |
Severe: Cannot or can only barely perform the task because of slowing, interruptions or decrements. |
|
NP3LGAGL |
UR |
Unable to Rate |
|
NP3LGAGR |
0 |
Normal: No problems. |
|
NP3LGAGR |
1 |
Slight: Any of the following: a) the regular rhythm is broken with one or two interruptions or hesitations of the movement; b) slight slowing; c) amplitude decrements near the end of the task. |
|
NP3LGAGR |
2 |
Mild: Any of the following: a) 3 to 5 interruptions during the movements; b) mild slowness; c) amplitude decrements midway in the task. |
|
NP3LGAGR |
3 |
Moderate: Any of the following: a) more than 5 interruptions during the movements or at least one longer arrest (freeze) in ongoing movement; b) moderate slowing in speed; c) amplitude decrements after the first movement. |
|
NP3LGAGR |
4 |
Severe: Cannot or can only barely perform the task because of slowing, interruptions or decrements. |
|
NP3LGAGR |
UR |
Unable to Rate |
|
NP3POSTR |
0 |
Normal: No problems. |
|
NP3POSTR |
1 |
Slight: Not quite erect, but posture could be normal for older person. |
|
NP3POSTR |
2 |
Mild: Definite flexion, scoliosis or leaning to one side, but patient can correct posture to normal posture when asked to do so. |
|
NP3POSTR |
3 |
Moderate: Stooped posture, scoliosis or leaning to one side that cannot be corrected volitionally to a normal posture by the patient. |
|
NP3POSTR |
4 |
Severe: Flexion, scoliosis or leaning with extreme abnormality of posture. |
|
NP3POSTR |
UR |
Unable to Rate |
|
NP3PRSPL |
0 |
Normal: No problems. |
|
NP3PRSPL |
1 |
Slight: Any of the following: a) the regular rhythm is broken with one or two interruptions or hesitations of the movement; b) slight slowing; c) the amplitude decrements near the end of the sequence. |
|
NP3PRSPL |
2 |
Mild: Any of the following: a) 3 to 5 interruptions during the movements; b) mild slowing; c) the amplitude decrements midway in the sequence. |
|
NP3PRSPL |
3 |
Moderate: Any of the following: a) more than 5 interruptions during the movement or at least one longer arrest (freeze) in ongoing movement; b) moderate slowing; c) the amplitude decrements starting after the first supination-pronation sequence. |
|
NP3PRSPL |
4 |
Severe: Cannot or can only barely perform the task because of slowing, interruptions or decrements. |
|
NP3PRSPL |
UR |
Unable to Rate |
|
NP3PRSPR |
0 |
Normal: No problems. |
|
NP3PRSPR |
1 |
Slight: Any of the following: a) the regular rhythm is broken with one or two interruptions or hesitations of the movement; b) slight slowing; c) the amplitude decrements near the end of the sequence. |
|
NP3PRSPR |
2 |
Mild: Any of the following: a) 3 to 5 interruptions during the movements; b) mild slowing; c) the amplitude decrements midway in the sequence. |
|
NP3PRSPR |
3 |
Moderate: Any of the following: a) more than 5 interruptions during the movement or at least one longer arrest (freeze) in ongoing movement; b) moderate slowing; c) the amplitude decrements starting after the first supination-pronation sequence. |
|
NP3PRSPR |
4 |
Severe: Cannot or can only barely perform the task because of slowing, interruptions or decrements. |
|
NP3PRSPR |
UR |
Unable to Rate |
|
NP3PSTBL |
0 |
Normal: No problems: Recovers with one or two steps. |
|
NP3PSTBL |
1 |
Slight: 3-5 steps, but subject recovers unaided. |
|
NP3PSTBL |
2 |
Mild: More than 5 steps, but subject recovers unaided. |
|
NP3PSTBL |
3 |
Moderate: Stands safely, but with absence of postural response; falls if not caught by examiner. |
|
NP3PSTBL |
4 |
Severe: Very unstable, tends to lose balance spontaneously or with just a gentle pull on the shoulders. |
|
NP3PSTBL |
UR |
Unable to Rate |
|
NP3PTRML |
0 |
Normal: No tremor. |
|
NP3PTRML |
1 |
Slight: Tremor is present but less than 1 cm in amplitude. |
|
NP3PTRML |
2 |
Mild: Tremor is at least 1, but less than 3 cm in amplitude. |
|
NP3PTRML |
3 |
Moderate: Tremor is at least 3, but less than 10 cm in amplitude. |
|
NP3PTRML |
4 |
Severe: Tremor is at least 10 cm in amplitude. |
|
NP3PTRML |
UR |
Unable to Rate |
|
NP3PTRMR |
0 |
Normal: No tremor. |
|
NP3PTRMR |
1 |
Slight: Tremor is present but less than 1 cm in amplitude. |
|
NP3PTRMR |
2 |
Mild: Tremor is at least 1, but less than 3 cm in amplitude. |
|
NP3PTRMR |
3 |
Moderate: Tremor is at least 3, but less than 10 cm in amplitude. |
|
NP3PTRMR |
4 |
Severe: Tremor is at least 10 cm in amplitude. |
|
NP3PTRMR |
UR |
Unable to Rate |
|
NP3RIGLL |
0 |
Normal: No rigidity. |
|
NP3RIGLL |
1 |
Slight: Rigidity only detected with activation maneuver. |
|
NP3RIGLL |
2 |
Mild: Rigidity detected without the activation maneuver, but full range of motion is easily achieved. |
|
NP3RIGLL |
3 |
Moderate: Rigidity detected without the activation maneuver, full range of motion is achieved with effort. |
|
NP3RIGLL |
4 |
Severe: Rigidity detected without the activation maneuver and full range of motion not achieved. |
|
NP3RIGLL |
UR |
Unable to Rate |
|
NP3RIGLU |
0 |
Normal: No rigidity. |
|
NP3RIGLU |
1 |
Slight: Rigidity only detected with activation maneuver. |
|
NP3RIGLU |
2 |
Mild: Rigidity detected without the activation maneuver, but full range of motion is easily achieved. |
|
NP3RIGLU |
3 |
Moderate: Rigidity detected without the activation maneuver, full range of motion is achieved with effort. |
|
NP3RIGLU |
4 |
Severe: Rigidity detected without the activation maneuver and full range of motion not achieved. |
|
NP3RIGLU |
UR |
Unable to Rate |
|
NP3RIGN |
0 |
Normal: No rigidity. |
|
NP3RIGN |
1 |
Slight: Rigidity only detected with activation maneuver. |
|
NP3RIGN |
2 |
Mild: Rigidity detected without the activation maneuver, but full range of motion is easily achieved. |
|
NP3RIGN |
3 |
Moderate: Rigidity detected without the activation maneuver, full range of motion is achieved with effort. |
|
NP3RIGN |
4 |
Severe: Rigidity detected without the activation maneuver and full range of motion not achieved. |
|
NP3RIGN |
UR |
Unable to Rate |
|
NP3RIGRL |
0 |
Normal: No rigidity. |
|
NP3RIGRL |
1 |
Slight: Rigidity only detected with activation maneuver. |
|
NP3RIGRL |
2 |
Mild: Rigidity detected without the activation maneuver, but full range of motion is easily achieved. |
|
NP3RIGRL |
3 |
Moderate: Rigidity detected without the activation maneuver, full range of motion is achieved with effort. |
|
NP3RIGRL |
4 |
Severe: Rigidity detected without the activation maneuver and full range of motion not achieved. |
|
NP3RIGRL |
UR |
Unable to Rate |
|
NP3RIGRU |
0 |
Normal: No rigidity. |
|
NP3RIGRU |
1 |
Slight: Rigidity only detected with activation maneuver. |
|
NP3RIGRU |
2 |
Mild: Rigidity detected without the activation maneuver, but full range of motion is easily achieved. |
|
NP3RIGRU |
3 |
Moderate: Rigidity detected without the activation maneuver, full range of motion is achieved with effort. |
|
NP3RIGRU |
4 |
Severe: Rigidity detected without the activation maneuver and full range of motion not achieved. |
|
NP3RIGRU |
UR |
Unable to Rate |
|
NP3RISNG |
0 |
Normal: No problems. Able to arise quickly without hesitation. |
|
NP3RISNG |
1 |
Slight: Arising is slower than normal; or may need more than one attempt; or may need to move forward in the chair to arise. No need to use the arms of the chair. |
|
NP3RISNG |
2 |
Mild: Pushes self up from arms of chair without difficulty. |
|
NP3RISNG |
3 |
Moderate: Needs to push off, but tends to fall back; or may have to try more than one time using arms of chair, but can get up without help. |
|
NP3RISNG |
4 |
Severe: Unable to arise without help. |
|
NP3RISNG |
UR |
Unable to Rate |
|
NP3RTALJ |
0 |
Normal: No tremor. |
|
NP3RTALJ |
1 |
Slight: < 1 cm in maximal amplitude. |
|
NP3RTALJ |
2 |
Mild: >= 1 cm but < 2 cm in maximal amplitude. |
|
NP3RTALJ |
3 |
Moderate: >= 2 cm but < 3 cm in maximal amplitude. |
|
NP3RTALJ |
4 |
Severe: >= 3 cm in maximal amplitude. |
|
NP3RTALJ |
UR |
Unable to Rate |
|
NP3RTALL |
0 |
Normal: No tremor. |
|
NP3RTALL |
1 |
Slight: < 1 cm in maximal amplitude. |
|
NP3RTALL |
2 |
Mild: >= 1 cm but < 3 cm in maximal amplitude. |
|
NP3RTALL |
3 |
Moderate: >= 3 cm but < 10 cm in maximal amplitude. |
|
NP3RTALL |
4 |
Severe: >= 10 cm in maximal amplitude. |
|
NP3RTALL |
UR |
Unable to Rate |
|
NP3RTALU |
0 |
Normal: No tremor. |
|
NP3RTALU |
1 |
Slight: < 1 cm in maximal amplitude. |
|
NP3RTALU |
2 |
Mild: >= 1 cm but < 3 cm in maximal amplitude. |
|
NP3RTALU |
3 |
Moderate: >= 3 cm but < 10 cm in maximal amplitude. |
|
NP3RTALU |
4 |
Severe: >= 10 cm in maximal amplitude. |
|
NP3RTALU |
UR |
Unable to Rate |
|
NP3RTARL |
0 |
Normal: No tremor. |
|
NP3RTARL |
1 |
Slight: < 1 cm in maximal amplitude. |
|
NP3RTARL |
2 |
Mild: >= 1 cm but < 3 cm in maximal amplitude. |
|
NP3RTARL |
3 |
Moderate: >= 3 cm but < 10 cm in maximal amplitude. |
|
NP3RTARL |
4 |
Severe: >= 10 cm in maximal amplitude. |
|
NP3RTARL |
UR |
Unable to Rate |
|
NP3RTARU |
0 |
Normal: No tremor. |
|
NP3RTARU |
1 |
Slight: < 1 cm in maximal amplitude. |
|
NP3RTARU |
2 |
Mild: >= 1 cm but < 3 cm in maximal amplitude. |
|
NP3RTARU |
3 |
Moderate: >= 3 cm but < 10 cm in maximal amplitude. |
|
NP3RTARU |
4 |
Severe: >= 10 cm in maximal amplitude. |
|
NP3RTARU |
UR |
Unable to Rate |
|
NP3RTCON |
0 |
Normal: No tremor. |
|
NP3RTCON |
1 |
Slight: Tremor at rest is present < 25% of the entire examination period. |
|
NP3RTCON |
2 |
Mild: Tremor at rest is present 26-50% of the entire examination period. |
|
NP3RTCON |
3 |
Moderate: Tremor at rest is present 51-75% of the entire examination period. |
|
NP3RTCON |
4 |
Severe: Tremor at rest is present > 75% of the entire examination period. |
|
NP3RTCON |
UR |
Unable to Rate |
|
NP3SPCH |
0 |
Normal: No speech problems. |
|
NP3SPCH |
1 |
Slight: Loss of modulation, diction or volume, but still all words easy to understand. |
|
NP3SPCH |
2 |
Mild: Loss of modulation, diction, or volume, with a few words unclear, but the overall sentences easy to follow. |
|
NP3SPCH |
3 |
Moderate: Speech is difficult to understand to the point that some, but not most, sentences are poorly understood. |
|
NP3SPCH |
4 |
Severe: Most speech is difficult to understand or unintelligible. |
|
NP3SPCH |
UR |
Unable to Rate |
|
NP3TTAPL |
0 |
Normal: No problems. |
|
NP3TTAPL |
1 |
Slight: Any of the following: a) the regular rhythm is broken with one or two interruptions or hesitations of the tapping movement; b) slight slowing; c) the amplitude decrements near the end of the ten taps. |
|
NP3TTAPL |
2 |
Mild: Any of the following: a) 3 to 5 interruptions during the tapping movements; b) mild slowing; c) the amplitude decrements midway in the task. |
|
NP3TTAPL |
3 |
Moderate: Any of the following: a) more than 5 interruptions during the tapping movements or at least one longer arrest (freeze) in ongoing movement; b) moderate slowing; c) amplitude decrements after the first tap. |
|
NP3TTAPL |
4 |
Severe: Cannot or can only barely perform the task because of slowing, interruptions or decrements. |
|
NP3TTAPL |
UR |
Unable to Rate |
|
NP3TTAPR |
0 |
Normal: No problems. |
|
NP3TTAPR |
1 |
Slight: Any of the following: a) the regular rhythm is broken with one or two interruptions or hesitations of the tapping movement; b) slight slowing; c) the amplitude decrements near the end of the ten taps. |
|
NP3TTAPR |
2 |
Mild: Any of the following: a) 3 to 5 interruptions during the tapping movements; b) mild slowing; c) the amplitude decrements midway in the task. |
|
NP3TTAPR |
3 |
Moderate: Any of the following: a) more than 5 interruptions during the tapping movements or at least one longer arrest (freeze) in ongoing movement; b) moderate slowing; c) amplitude decrements after the first tap. |
|
NP3TTAPR |
4 |
Severe: Cannot or can only barely perform the task because of slowing, interruptions or decrements. |
|
NP3TTAPR |
UR |
Unable to Rate |
|
PDSTATE |
1 |
Fluctuator - ON during exam |
|
PDSTATE |
3 |
Fluctuator - OFF during exam |
|
PDSTATE |
OFF |
Off is the typical functional state when participants have a poor response in spite of taking medications |
|
PDSTATE |
ON |
On is the typical functional state when patients are receiving medication and have a good response |
|
PDTRTMNT |
0 |
No |
|
PDTRTMNT |
1 |
Yes |
Missing Columns¶
ITM_NAME |
DSCR_1.0 |
|---|---|
ANNUAL_TIME_BTW_DOSE_NUP |
Hours between dose and NUPDRS (max 99) |
DBS_STATUS |
0 = OFF, 1 = ON |
ON_OFF_DOSE |
PD Med None=” “,>=6 hr or PDSTATE OFF and >=3 hr=”1”,<6 hr=”2” |
PD_MED_USE |
0=No,1=Lv,2=Ag,3=Oth,4=1+3,5=1+2,6=2+3,7=1+2+3 |
PN3RIGRL |
3.3d Rigidity - RLE |
STAFFCD |
Examiner |
Details¶
This table is a combination, in PPMI 2.0, of 3 CRFs: MDS UPDRS Part III (No Treatment), (OFF State), and (ON State). The CRF used for each record in this table is recorded in PAG_NAME (not listed below since it is a standard variable present in all tables derived from CRFs). Users of the EDC decide which form to complete based on information captured in NUPDRDOSE (NUPDRDOSER at remote visits):
Participants not taking a Levodopa-Equivalent treatment will complete the (No Treatment) CRF.
Participants being treated will ideally arrive to their annual visit in the OFF State (not having recently taken medication or not responding to their medication) and will complete the OFF State CRF.
Participants being treated will subsequently take their medication and complete the ON State CRF while in the ON State (having recently taken medication and responding well to it).
No source CRF is listed for PPMI 1.0 since the standard MDS-UPDRS Scale was used.
Definition of ON and OFF State
The definition of ON and OFF States have changed slightly from PPMI 1.0 to 2.0. In PPMI 1.0 more emphasis was put on marking a completed asssessment as having been in the ON or OFF state based on the time since a participant’s last dose of medication. In 2.0 the emphasis is more on a participant’s response to the treatment and while the time since last dose is recorded in NUPDRDOSE, the ON or OFF State CRF is completed based on whether the participant is experiencing a treatment response at the time of the exam.
The PDTRTMNT variable is collected in all of the NUPDRS3 forms and indicates whether the participant is being treated for Parkinson’s Disease. The PDSTATE variable is asked in the ON and OFF NUPDRS3 forms and asks whether the particiapnt is ON or OFF of PD treatment, according to the above definition.
The HRPOSTMED, HRDBSOFF, and HRDBSON variables indicate the amount of time between a change in treatment state (taking medication or turning on or off the DBS machine) and the NUPDRS3 exam. They are calculated by comparing PDMEDTM (if PDMEDDT is the same as INFODT), DBSOFFTM, or DBSONTM to EXAMTM, all of which are derived from information in the NUPDRDOSE form.
Remote Visits
At remote visits the MDS-UPDRS Part III is ideally not repeated as it is at annual visits. Participants being treated should be in the ON State. Since the assessment is not conducted in person, Rigidity (NP3RIGN, NP3RIGRU, NP3RIGLU, NP3RIGRL. and NP3RIGLL) and Postural Stability (NP3PSTBL) will be marked as “Unable to Rate”. The entire assessment will be skipped if the visit can only be conducted over the phone and without video.
In PPMI 1.0 the MDS-UPDRS Part III was not captured at remote (telephone) visits at all.
ITM_TYPE
ITM_TYPE has changed for nearly every variable because in PPMI 2.0 the “Unable to Rate” option is captured in the list of possible values as “UR”, while in PPMI 1.0 only the numeric option 0-4 were listed.
NP3RIGRL
This variable is listed as ADDED because in PPMI 1.0 it was erroneously named PN3RIGRL (listed here under Missing Columns).
Codebook
Besides DYSKIRAT, no variables from the NUPDRS3 table were included in PPMI 1.0’s Code List. In 2.0, all variables from the NUPDRS3 table have been added to the codebook to allow for documentation on what the different codes mean for each question. The DIFF REASON of “DESIGN” indicates that these were added to the code book as a result of the design of the CRF in the EDC which includes both the numeric and text option.